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These results, together with a former report displaying that a little-molecule ACKR3 agonist CCX771 displays anxiolytic-like conduct in mice,2 support the thought of targeting ACKR3 as a novel way to modulate the opioid program, which could open new therapeutic avenues for opioid-relevant Issues.Tabernaemontana divaricata Conolidine can be an indol